1 September – Foreign Secretary Dominic Raab appears before MPs of the Foreign Affairs Select Committee and is questioned about the ending of the UK's campaign in Afghanistan.
6 September The government announces a plan to increase the limit for human sperm, egg and embryo cryopreservation from 10 to 55 years.
COVID-19 in the UK: The total number of confirmed infections since the start of the pandemic exceeds 7 million.[310]
7 September – In the Commons, Johnson reveals the government's long-awaited plan for social care reforms, including a 1.25% rise in National Insurance to raise £36bn over three years, and a cap of £86,000 on lifetime care costs in England.[311]
8 September – MPs vote in favour of the government's NHS and social care tax rise plan by 319 votes to 248, a majority of 71.[312]
9 September – COVID-19 vaccination in the United Kingdom: The JCVI approves the use of the Pfizer–BioNTech and Oxford–AstraZeneca vaccines as COVID-19 booster shots, paving the way for a rollout ahead of the winter.[313]
11 September – British player Emma Raducanu wins the 2021 US Open Women's Singles on her first attempt. Raducanu becomes the first qualifier in history, male or female, to win a Grand Slam tournament and the first female British player to win a major since Virginia Wade at Wimbledon in 1977. She also won the tournament without losing a set. She is the second British player to do this male or female after Angela Mortimer Barrett at the 1958 Australian Championships.[314]
12 September – COVID-19 in the UK: A plan for vaccine passports in England is ditched by the government, but kept "in reserve" should it be needed over autumn or winter.[315]
13 September – COVID-19 vaccination in the United Kingdom: The UK's four chief medical officers recommend that children aged 12–15 should be vaccinated against COVID-19, initially with a single dose, leaving the possibility for a second dose in spring 2022.[316]
14 September – COVID-19 vaccination in the United Kingdom: The JCVI recommends a booster shot against COVID-19 for the over 50s and at-risk groups, preferably the Pfizer–BioNTech vaccine, meaning about 30 million adults should receive a third dose.[317]
15 SeptemberThe Consumer Price Index jumps from 2 to 3.2%, its biggest increase since 1997.[318]
Johnson reshuffles the cabinet.[319] Dominic Raab is appointed Deputy Prime Minister of the United Kingdom.
The UK joins AUKUS, a trilateral security pact with Australia and the United States, to counter the influence of China.[320]
16 SeptemberCOVID-19 vaccination in the United Kingdom: The booster programme begins in England and Wales, starting with NHS staff.[321]
Co-op Food announces a partnership with Amazon Prime, enabling same-day grocery deliveries, while also expanding the use of robots from 200 to 500 units.[322]
18 September – Princess Beatrice gives birth to her first child, a baby girl.[323]
20 SeptemberBusiness Secretary Kwasi Kwarteng holds crisis talks with industry bosses, as firms struggle to stay afloat amid a surge in natural gas wholesale prices.[324][325]
The Northern line extension to Battersea opens, the first major expansion of the London Underground in over 20 years.[326]
23 September – The government announces plans to prevent employers in the hospitality industry from withholding tips given by customers to staff.[327]

Empty pumps during the Autumn fuel panic on 25 September
6 September The government announces a plan to increase the limit for human sperm, egg and embryo cryopreservation from 10 to 55 years.
COVID-19 in the UK: The total number of confirmed infections since the start of the pandemic exceeds 7 million.[310]
7 September – In the Commons, Johnson reveals the government's long-awaited plan for social care reforms, including a 1.25% rise in National Insurance to raise £36bn over three years, and a cap of £86,000 on lifetime care costs in England.[311]
8 September – MPs vote in favour of the government's NHS and social care tax rise plan by 319 votes to 248, a majority of 71.[312]
9 September – COVID-19 vaccination in the United Kingdom: The JCVI approves the use of the Pfizer–BioNTech and Oxford–AstraZeneca vaccines as COVID-19 booster shots, paving the way for a rollout ahead of the winter.[313]
11 September – British player Emma Raducanu wins the 2021 US Open Women's Singles on her first attempt. Raducanu becomes the first qualifier in history, male or female, to win a Grand Slam tournament and the first female British player to win a major since Virginia Wade at Wimbledon in 1977. She also won the tournament without losing a set. She is the second British player to do this male or female after Angela Mortimer Barrett at the 1958 Australian Championships.[314]
12 September – COVID-19 in the UK: A plan for vaccine passports in England is ditched by the government, but kept "in reserve" should it be needed over autumn or winter.[315]
13 September – COVID-19 vaccination in the United Kingdom: The UK's four chief medical officers recommend that children aged 12–15 should be vaccinated against COVID-19, initially with a single dose, leaving the possibility for a second dose in spring 2022.[316]
14 September – COVID-19 vaccination in the United Kingdom: The JCVI recommends a booster shot against COVID-19 for the over 50s and at-risk groups, preferably the Pfizer–BioNTech vaccine, meaning about 30 million adults should receive a third dose.[317]
15 SeptemberThe Consumer Price Index jumps from 2 to 3.2%, its biggest increase since 1997.[318]
Johnson reshuffles the cabinet.[319] Dominic Raab is appointed Deputy Prime Minister of the United Kingdom.
The UK joins AUKUS, a trilateral security pact with Australia and the United States, to counter the influence of China.[320]
16 SeptemberCOVID-19 vaccination in the United Kingdom: The booster programme begins in England and Wales, starting with NHS staff.[321]
Co-op Food announces a partnership with Amazon Prime, enabling same-day grocery deliveries, while also expanding the use of robots from 200 to 500 units.[322]
18 September – Princess Beatrice gives birth to her first child, a baby girl.[323]
20 SeptemberBusiness Secretary Kwasi Kwarteng holds crisis talks with industry bosses, as firms struggle to stay afloat amid a surge in natural gas wholesale prices.[324][325]
The Northern line extension to Battersea opens, the first major expansion of the London Underground in over 20 years.[326]
23 September – The government announces plans to prevent employers in the hospitality industry from withholding tips given by customers to staff.[327]

Empty pumps during the Autumn fuel panic on 25 September
26 September – Amid panic buying at petrol stations during the fuel supply crisis, ministers suspend competition laws to enable fuel suppliers to talk to one another and prioritise locations most in need.
28 SeptemberKatie Price is hospitalised after a car crash in Horsham. The following day, she pleads guilty to three charges of drunk driving, driving without insurance and driving while disqualified.[329]
The United Kingdom's international vehicle registration code is officially changed from "GB" to "UK", after more than 110 years.[330]
29 September – Labour leader Keir Starmer gives his first in-person speech at the party's annual conference.[331]
30 September – Former police officer Wayne Couzens, who pleaded guilty to the murder of Sarah Everard, is sentenced at the Old Bailey to a whole-life tariff.[332] Lord Justice Fulford calls the case "devastating, tragic and wholly brutal" and tells Couzens he has eroded public confidence in the police
28 SeptemberKatie Price is hospitalised after a car crash in Horsham. The following day, she pleads guilty to three charges of drunk driving, driving without insurance and driving while disqualified.[329]
The United Kingdom's international vehicle registration code is officially changed from "GB" to "UK", after more than 110 years.[330]
29 September – Labour leader Keir Starmer gives his first in-person speech at the party's annual conference.[331]
30 September – Former police officer Wayne Couzens, who pleaded guilty to the murder of Sarah Everard, is sentenced at the Old Bailey to a whole-life tariff.[332] Lord Justice Fulford calls the case "devastating, tragic and wholly brutal" and tells Couzens he has eroded public confidence in the police
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